It is also believed to be a PDE4-inhibitor due to a strikingly similar chemical makeup and effects profile in comparison to a chemical named rolipram. mesembrine is a serotonin reuptake inhibitor. Mesembrine is a major alkaloid present in Sceletium tortuosum. The alkaloids contained in Kanna are psychoactive they include: mesembrine, mesembrenone, mesembrenol and tortuosamine. It is important to have a good source of quality kanna, there are big differences in the quality of kanna, "wild crafted" is about equal to "swag", green house/professionally tended is much higher quality and is considered "dank". Kanna also slowly loses it's potency over time. although the process seems to involve crushing/cutting then heating (in the hot sun) rather than actual fermentation action by bacteria. Kanna can not simply be picked and smoked or chewed, it must be dried first. Is the Traditional Method with the presumed highest bioavailability, Chewing whole leaf or tea cut is optimal (quid) Some users put kanna powder under their tounge, or stick some powder in a piece of gum and chew on it.
500mg would be considered an intense overdose if snorted, while it's an active dose for oral use. If more is needed, your kanna is extremely weak. A dose of 20mg-100mg should be sufficient. Snorting Kanna is by far the strongest method of administration but it also makes it a extremely quick experience, It may produce a strong burning sensation in the nasal passage, as most drugs do when snorted (with the possible exception of cocaine). A dose of 50mg-2000mg should be sufficient, although reports vary. Kanna should always be taken on an empty stomach when used orally. If the kanna extract is of good quality and not "cut" or of old stock the effects are almost immediate.
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